is a rare neurological disorder characterized by severe and recurrent unilateral (affecting one side) orbital or periorbital pain, along with other neurological symptoms such as paralysis or weakness of the eye muscles, double vision (diplopia), and a drooping eyelid (ptosis). The pain is usually located around the eye and may extend to the forehead and temple.


  • Is not fully understood, but it is believed to result from inflammation or compression of the cavernous sinus or the superior orbital fissure. These are areas in the skull through which important blood vessels and nerves pass, including those responsible for eye movement and sensation in the face. In some cases, THS may be associated with underlying inflammatory conditions such as granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis).

SIGN AND SYMPTOMS of Tolosa-Hunt syndrome:

  • Unilateral Pain: The most prominent symptom is severe, stabbing or aching pain around the eye or in the periorbital area. The pain can be continuous or intermittent and is often described as excruciating.
  • Ophthalmoplegia: This refers to weakness or paralysis of the muscles that control eye movements. It can lead to double vision and difficulty moving the eye in various directions.
  • Diplopia: Double vision occurs due to the inability of the affected eye to move properly in coordination with the other eye.
  • Ptosis: Drooping of the upper eyelid on the affected side.
  • Duration and Recurrence: The symptoms of THS can last for weeks to months, but they usually resolve spontaneously. The condition may recur in the same or opposite eye.

DIAGNOSIS: OF THS involves a thorough clinical evaluation, including a detailed medical history and neurological examination. Imaging studies such as magnetic resonance imaging (MRI) or computed tomography (CT) scans may be conducted to rule out other potential causes of the symptoms.


  1. Hypericum perforatum (St. John's Wort): This remedy is often associated with injuries to nerves, including nerve pain, shooting pains, and injuries to areas rich in nerves (fingers, toes, spine). It may be helpful for cases of trigeminal neuralgia, sciatica, and other nerve-related pain.
  2. Spigelia anthelmia: This remedy is sometimes used for left-sided neuralgic pains that feel like electric shocks or are described as stabbing, throbbing, or tearing in nature. It is often associated with conditions affecting the eye, face, and heart.
  3. Magnesia phosphorica: This remedy is known for its use in neuralgic pains that are accompanied by muscle spasms or cramps. It is often used for menstrual cramps, facial neuralgia, and other shooting pains.
  4. Arsenicum album: This remedy may be considered for burning, shooting pains that are relieved by warmth and worsened at night. It is sometimes used for conditions such as trigeminal neuralgia and shingles.
  5. Mezereum: This remedy is used for neuralgic pains that feel like burning, stinging, or shooting, often along the course of a nerve. It may be considered for conditions like postherpetic neuralgia.
  6. Rhus toxicodendron: This remedy is often associated with pains that are worse upon initial movement but improve with continued motion or warmth. It may be used for conditions like sciatica and herpes zoster (shingles).