Phaeohyphomycoses are a heterogenous group of fungal diseases caused by a large number (more than 70) of dematiaceous fungi. In phaeohyphomycosis, the tissue form of the fungus is predominantly mycelial (filamentous), as opposed to euphaeohyphomycosis (grain) or chromoblastomycosis (sclerotic body). Disease may be superficial subcutaneous or deep.
The most serious is cerebral phaeohyphomycosis, which presents with a ring-enhancing, space-occupying cerebral lesion.
Optimal therapy for this condition has not been established, but treatment usually consists of neurosurgical intervention and antifungal (usually triazole) therapy.
Causative agents are Cladophialophora bantiana, Fonsecaea spp. and Rhinocladiella mackenziei, which occurs in the Middle East and is usually fatal.
The medicines that can be thought of use are:-