OBESITY AND INSULIN RESISTANCE
Obesity (central) is recognized as an important contributory factor. Apart from excess production of androgens, obesity is also associated with reduced SHBG. It also induces insulin resistance and hyperinsulinemia which in turn increases the gonadal androgen production. PCOS is thought to have a dominant mode of inheritance as about 50% of first degree relatives have PCOS.
Etiology of insulin resistance is unknown. Mutations of the insulin receptor gene in the peripheral target tissues and reduced tyrosine autophosphorylation of the insulin receptor, is currently thought to be an important cause. Increased central body fat leads to android obesity long-term consequences in a patient suffering from PCOS includes: The excess androgens (mainly androstenedione) either from the ovaries or adrenals are peripherally aromatized to estrone (E1). There is concomitant diminished SHBG. Cumulative excess unbound E2 and estrone results in a tonic hyperestrogenic state.There is endometrial hyperplasia.
HOMEOPATHIC MANAGEMENT OF OBESITY ASSOCIATED WITH INSULIN RESISTANCE: -
The medicines that can be thought of use are:-