Male hypogonadism is a condition in which the body doesn't produce enough of the hormone that plays a key role in masculine growth and development during puberty (testosterone) or enough sperm or both.You can be born with male hypogonadism, or it can develop later in life, often from injury or infection. The effects — and what you can do about them — depend on the cause and at what point in your life male hypogonadism occurs.
- In adult males, hypogonadism can alter certain masculine physical characteristics and impair normal reproductive function. Early signs and symptoms might include:
- Decreased sex drive
- Decreased energy
- Over time, men with hypogonadism can develop:
- Erectile dysfunction
- Decrease in hair growth on the face and body
- Decrease in muscle mass
- Development of breast tissue (gynecomastia)
- Loss of bone mass (osteoporosis)
- Difficulty concentrating
- Hot flashes
Risk factors for hypogonadism include:
- Previous chemotherapy or radiation therapy
Male hypogonadism means the testicles don't produce enough of the male sex hormone testosterone. There are two basic types of hypogonadism:
- Primary : This type of hypogonadism — also known as primary testicular failure — originates from a problem in the testicles.
- Secondary : This type of hypogonadism indicates a problem in the hypothalamus or the pituitary gland — parts of the brain that signal the testicles to produce testosterone. The hypothalamus produces gonadotropin-releasing hormone, which signals the pituitary gland to make follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Luteinizing hormone then signals the testes to produce testosterone.
- Klinefelter syndrome.This condition results from a congenital abnormality of the sex chromosomes, X and Y. A male normally has one X and one Y chromosome. In Klinefelter syndrome, two or more X chromosomes are present in addition to one Y chromosome.
- Undescended testicles.Before birth, the testicles develop inside the abdomen and normally move down into their permanent place in the scrotum. Sometimes one or both of the testicles aren't descended at birth.
- Mumps orchitis.A mumps infection involving the testicles that occurs during adolescence or adulthood can damage the testicles, affecting the function of the testicles and testosterone production.
- Too much iron in the blood can cause testicular failure or pituitary gland dysfunction, affecting testosterone production.
- Injury to the testicles.Because they're outside the abdomen, the testicles are prone to injury. Damage to both testicles can cause hypogonadism. Damage to one testicle might not impair total testosterone production.
- Cancer treatment.Chemotherapy or radiation therapy for the treatment of cancer can interfere with testosterone and sperm production. The effects of both treatments often are temporary, but permanent infertility may occur.
Although many men regain their fertility within a few months after treatment, preserving sperm before starting cancer therapy is an option for men.
In secondary hypogonadism, the testicles are normal but don't function properly due to a problem with the pituitary or hypothalamus. A number of conditions can cause secondary hypogonadism, including:
- Kallmann's syndrome.This is an abnormal development of the area of the brain that controls the secretion of pituitary hormones (hypothalamus). This abnormality can also affect the ability to smell (anosmia) and cause red-green color blindness.
- Pituitary disorders.An abnormality in the pituitary gland can impair the release of hormones from the pituitary gland to the testicles, affecting normal testosterone production. A pituitary tumor or other type of brain tumor located near the pituitary gland may cause testosterone or other hormone deficiencies.
Also, treatment for a brain tumor, such as surgery or radiation therapy, can affect the pituitary gland and cause hypogonadism.
- Inflammatory disease.Certain inflammatory diseases, such as sarcoidosis, histiocytosis and tuberculosis, involve the hypothalamus and pituitary gland and can affect testosterone production.
- HIV/AIDS.HIV/AIDS can cause low levels of testosterone by affecting the hypothalamus, the pituitary and the testes.
- The use of certain drugs, such as opiate pain medications and some hormones, can affect testosterone production.
- Being significantly overweight at any age might be linked to hypogonadism.
- As men age, there's a slow, progressive decrease in testosterone production. The rate varies greatly.
The complications of untreated hypogonadism differ depending on when it develops — during fetal development, puberty or adulthood.
Complications might include:
- Abnormal genitalia
- Enlarged male breasts (gynecomastia)
- Erectile dysfunction
Agnus Castus --Yellow discharge from urethra. No erections. Impotence. Parts cold, relaxed. Desire gone, Scanty emission without ejaculation. Loss of prostatic fluid on straining. Gleety discharge. Testicles, cold, swollen, hard, and painful.
CALADIUM -Pruritus. Glans very red. Organs seem larger, puffed, relaxed, cold, sweating; skin of scrotum thick. Erections when half-asleep; cease when fully awake. Impotency; relaxation of penis during excitement. No emission and no orgasm during embrace.
Sabal Serrulata-Prostatic troubles; enlargement; discharge of prostatic fluid. Wasting of testes and loss of sexual power. Coitus painful at the time of emission. Sexual neurotics. Organs feel cold.
Nuphar Luteum--Complete absence of sexual desire; parts relaxed; penis retracted. Impotency, with involuntary emissions during stool, when urinating. Spermatorrhœa. Pain in testicles and penis.
Acid Phos -Emissions at night and at stool. Seminal vesiculitis (Oxal acid). Sexual power deficient; testicles tender and swollen. Parts relax during embrace (Nux). Prostatorrhśa, even when passing a soft stool. Eczema of scrotum. Śdema of prepuce, and swollen glans-penis
Selenium -Dribbling of semen during sleep. Dribbling of prostatic fluid. Irritability after coitus. Loss of sexual power, with lascivious fancies. Increases desire, decreases ability. Semen thin, odorless. Sexual neurasthenia. On attempting coition, penis relaxes. Hydrocele.