Hirayama disease also known as Monomelic amyotrophy (MMA) is a rare motor neuron disease first described in 1959 in Japan. Its symptoms usually appear about two years after adolescent growth spurt and is significantly more common in males, with an average age of onset between 15 and 25 years. MMA is reported most frequently in Asia but has a global distribution. It is typically marked by insidious onset of muscle atrophy of an upper limb, which plateaus after two to five years from which it neither improves nor worsens. There is no pain or sensory loss associated with MMA. MMA is not believed to be hereditary.


In terms of the signs and symptoms that are consistent for an individual who has monomelic amyotrophy are the following:

  • Muscle weakness
  • Fasciculations
  • Tremor
  • Cold hands
  • Muscle cramps
  • Atrophy of hand and forearm
  • Muscle Loss
  • Sharp pains (from neck to hand)

Initially most people notice weakness in one hand; they may feel contracture of middle and ring finger and notice a thinning of the sub digital palm of the affected fingers. Progress of the condition varies, and weakness in the arm ranges from minimal to significant. Fasciculations are uncommon (>20%); increased weakness under cold conditions is commonly reported (cold paresis).


Homoeopathy today is a rapidly growing system and is being practiced all over the world. It strength lies in its evident effectiveness as it takes a holistic approach towards the sick individual through promotion of inner balance at mental, emotional, spiritual and physical levels. When is concerned there are many effective medicines available in Homoeopathy, but the selection depends upon the individuality of the patient, considering mental and physical symptoms

Few homoeopathic medicine can be thought of in the treatment of Hirayama disease are:

medorrhinum, causticum, gelsemium, sepia, lachesis, etc.