Hereditary spherocytosis is a rare inherited disorder that affects the red blood cells. It is characterized by the presence of spherical-shaped red blood cells instead of the normal biconcave shape. These abnormal red blood cells are more prone to premature destruction, leading to anemia, jaundice, and an enlarged spleen.


  • ANK1: Mutations in the ANK1 gene, which provides instructions for producing a protein called ankyrin-1. Ankyrin-1 helps maintain the normal shape and stability of red blood cells.
  • SPTB: Mutations in the SPTB gene, Spectrin-beta is involved in the structural integrity of red blood cells.
  • SPTA1: Mutations in the SPTA1 geneSpectrin-alpha is another important component of the red blood cell structure.
  • EPB42: Mutations in the EPB42 gene, Protein 4.2 plays a role in stabilizing the red blood cell membrane.


  • Anemia: Occurs due to the premature destruction of red blood cells. Anemia can cause fatigue, weakness, and pale skin.
  • Jaundice: excessive breakdown of hemoglobin. This can lead to an accumulation of bilirubin, a yellow pigment, causing jaundice.
  • Enlarged Spleen: the spleen works harder to remove the spherocytes, leading to its enlargement.
  • Gallstones
  • Episodes of Hemolytic Crisis: During a crisis, there is a sudden increase in the destruction of red blood cells, leading to a severe drop in hemoglobin levels.
  • Severe fatigue
  • Shortness of breath
  • Rapid heart rate.
  • Nausea and vomiting
  • Abdominal pain and colic
  • Pale and yellow skin.


  • Complete Blood Count
  • Reticulocyte Count
  • Blood Smear Examination
  • Bilirubin Levels
  • Osmotic Fragility Test
  • Genetic Testing


  1. Ferrum phosphoricum: This remedy is commonly used in homeopathy for general anemia symptoms, including weakness, fatigue, and pallor. anæmic with the false plethora and easy flushing of Ferrum. increases hemoglobin. In pale, anæmic subjects, with violent local congestions. Hæmorrhages, bright from any orifice.
  2. Natrum muriaticum: It is often suggested for anemia with symptoms such as weakness, dizziness, and an aversion to salt. A great remedy for certain forms of intermittent fever, anemia, chlorosis, many disturbances of the alimentary tract and skin. Great debility; most weakness felt in the morning in bed.
  3. Calcarea phosphorica: This remedy may be recommended for anemia associated with slow recovery, weakness, and poor assimilation of nutrients. Anemic children who are peevish, flabby, have cold extremities and feeble digestion. Numbness and crawlingare characteristic sensations, and tendency to perspiration and glandular enlargement are symptoms it shares with the carbonate. Scrofulosis, chlorosis and phthisis.
  4. China officinalis: China, also known as Cinchona, is used for anemia with symptoms such as weakness, fatigue, and a tendency to experience excessive gas and bloating.