Hallermann-Streiff syndrome (HSS) is a very rare genetic disorder that has a characteristic facial appearance, dental abnormalities, hypotrichosis, skin atrophy, proportionate short stature, and ophthalmic features including microphthalmia and congenital bilateral cataracts. The disease was first discussed by Aubry in the late 1800s, but it was documented as a distinct entity by Hallermann in 1948 and Streiff in 1950.
The causative gene for HSS is yet to be determined. Previously, mutations in the GJA1 gene were thought to be contributing to the disease due to a similar phenotype in patients with these mutations. However, the GJA1 mutation phenotype was ultimately recognized to be different from the typical manifestations found in HSS.
Craniofacial – previously described as “bird-like” facies, but this terminology is no longer in use
SKIN AND HAIR
Ophthalmic -Present in approximately 90% of patients
INTELLECTUAL DISABILITY - Majority of patients have normal mental development; however, some have intellectual disability.
Homoeopathy today is a rapidly growing system and is being practiced all over the world. It strength lies in its evident effectiveness as it takes a holistic approach towards the sick individual through promotion of inner balance at mental, emotional, spiritual and physical levels. When is concerned there are many effective medicines available in Homoeopathy , but the selection depends upon the individuality of the patient , considering mental and physical symptoms
Few homoeopathic medicine can be thought of in the treatment of Hallermann-Streiff syndrome are:
medorrhinum, helleborus, hyoscyamus, zincum met., silicea, etc.