Is a kidney disorder that affects the glomeruli, which are the tiny filtering units within the kidneys. FSGS is characterized by scarring (sclerosis) of some segments of the glomeruli, leading to impaired kidney function and the leakage of protein into the urine.

FSGS can be categorized into several types, and some of them are associated with genetic factors, meaning they can be inherited within families. Here are some of the inherited FSGS syndromes:

Autosomal Dominant FSGS: This is the most common inherited form of FSGS. It is caused by mutations in genes that encode proteins involved in the structure and function of the glomeruli. Mutations in genes such as ACTN4, TRPC6, INF2, and others have been linked to autosomal dominant FSGS. If a parent carries a mutation in one of these genes, there's a 50% chance of passing the mutation on to their offspring.


  • Autosomal Recessive FSGS: This form of FSGS is less common and tends to present earlier in life. It is caused by mutations in genes that are critical for the proper function of the glomeruli. Mutations in genes like NPHS1, NPHS2, and WT1 can lead to autosomal recessive FSGS. In this case, both parents would need to carry a mutation in the same gene for the condition to manifest in their child.
  • CoQ2 Deficiency: This is a rare genetic disorder caused by mutations in the COQ2 gene. It leads to mitochondrial dysfunction and can result in FSGS, among other symptoms.
  • Denys-Drash Syndrome: This is a rare genetic disorder caused by mutations in the WT1 gene. It is characterized by FSGS, kidney abnormalities, and a high risk of developing kidney tumors.
  • Pierson Syndrome: This is another rare genetic disorder caused by mutations in the LAMB2 gene. It leads to kidney disease, eye abnormalities, and neurological issues.
  • Alport Syndrome: While not exactly an FSGS syndrome, Alport syndrome is a genetic disorder that affects the glomeruli and can lead to proteinuria and kidney dysfunction. It is caused by mutations in genes involved in collagen production, such as COL4A3, COL4A4, and COL4A5.


  • Proteinuria: One of the hallmark features of FSGS is the presence of excess protein in the urine, a condition known as proteinuria. This can lead to frothy or foamy urine.
  • Edema: Edema refers to swelling, typically in the ankles, legs, and sometimes in the face or hands. It occurs as a result of fluid retention due to impaired kidney function.
  • Hypertension: High blood pressure can develop as a consequence of kidney dysfunction. FSGS can disrupt the normal regulation of blood pressure, leading to hypertension.
  • Reduced Urine Output: Some individuals with FSGS may notice a decrease in the amount of urine produced, a condition known as oliguria. This can be due to reduced kidney function.
  • Fatigue: Kidney dysfunction can lead to anemia (low red blood cell count), which can cause fatigue, weakness, and general feelings of tiredness.
  • Swelling Around the Eyes: Swelling around the eyes, known as periorbital edema, can be an early sign of FSGS.
  • Abdominal Pain: Some individuals with FSGS may experience abdominal discomfort or pain, which can be related to fluid retention and pressure within the abdomen.
  • Hyperlipidemia: FSGS can lead to elevated levels of cholesterol and other lipids (hyperlipidemia) in the blood.
  • Kidney Dysfunction: As FSGS progresses, it can lead to a decline in kidney function, which might result in increased levels of waste products in the blood (azotemia) and altered electrolyte balance.
  • Nephrotic Syndrome: FSGS is a common cause of nephrotic syndrome, a condition characterized by proteinuria, hypoalbuminemia (low levels of albumin in the blood), edema, and elevated blood lipids.


  • Medical History and Physical Examination:
  • The doctor will ask about your symptoms, medical history, family history of kidney disease, and any relevant factors such as medications or illnesses that could contribute to kidney problems.
  • They will also conduct a physical examination to assess for signs of edema (swelling), hypertension (high blood pressure), and other symptoms related to kidney dysfunction.
  • Laboratory Tests:
  • Urinalysis: A urine sample will be analyzed for the presence of proteinuria (excess protein in the urine) and other abnormalities.
  • Blood Tests: Blood tests can help assess kidney function (creatinine and blood urea nitrogen levels), protein levels, lipid profile, and electrolyte balance.
  • Serum Albumin: A low serum albumin level can indicate nephrotic syndrome, which is often associated with FSGS.
  • Imaging Studies:
  • Ultrasound: An ultrasound of the kidneys may be performed to assess their size, shape, and structure.
  • CT Scan or MRI: These imaging techniques can provide detailed images of the kidneys and surrounding structures, helping to rule out other causes of kidney dysfunction.
  • Kidney Biopsy:
  • A kidney biopsy is often considered the gold standard for diagnosing FSGS. During this procedure, a small sample of kidney tissue is taken for examination under a microscope.
  • The biopsy helps determine the presence of glomerular scarring (sclerosis) and the pattern of involvement, which is characteristic of FSGS. It also helps rule out other kidney disorders.
  • Kidney biopsies are generally performed by a nephrologist using local anesthesia. The tissue sample is then examined by a pathologist.
  • Genetic Testing:
  • In cases where there is suspicion of inherited forms of FSGS, genetic testing may be considered. This involves analyzing specific genes associated with FSGS and related kidney disorders.
  • Other Tests:
  • In some cases, additional tests may be conducted to rule out secondary causes of FSGS, such as infections, autoimmune disorders, or certain medications.


  1. Berberis Vulgaris: This remedy is sometimes used for kidney and urinary tract issues, including kidney stones and pain in the renal region.
  2. Cantharis: Cantharis is often used for urinary tract infections, including those that involve burning sensations during urination.
  3. Apis Mellifica: This remedy may be considered for kidney and urinary conditions involving inflammation, swelling, and burning sensations.
  4. Lycopodium: Lycopodium may be recommended for conditions related to kidney dysfunction, urinary retention, and other urinary issues.
  5. Sarsaparilla: Sarsaparilla is sometimes used for kidney stone issues and pain associated with kidney problems.
  6. Terebinthina: This remedy may be considered for inflammation and pain related to kidney infections or kidney damage.