Microbiology and Epidemiology: -
The endemic treponematoses—yaws (Treponema pallidum subspecies pertenue), endemic syphilis (T. pallidum subspecies endemicum), and pinta (T. carateum)—are nonvenereal chronic diseases acquired during childhood and caused by organisms closely related to the agent of syphilis, T. pallidum subspecies pallidum.
CLINICAL MANIFESTATIONS: -
The major clinical distinctions made between venereal syphilis and the
nonvenereal treponematoses are the apparent lack of congenital transmission and of CNS involvement in the nonvenereal infections. However, these distinctions may not be entirely accurate.
– 3–4 weeks after acquisition of the organism, the pt develops a papule that ultimately enlarges, is associated with regional lymphadenopathy, and heals spontaneously within 6 months.
– Late gummatous lesions of the skin and long bones affect 10% of untreated persons and are similar to the destructive lesions of leprosy and leishmaniasis.
Diagnosis is based on clinical presentation, dark-field microscopy of scrapings from lesions, and serologic testing.
The medicines that can be thought of use are:-