Blue sclera is caused by thinness and transparency of the collagen fibers of the sclera that allow visualization of the underlying uvea (Figure 1). The sclera is the white outer coat of the eye, surrounding the iris may be thinned in congenital diseases such as osteogenesis imperfect.

Other diseases associated with blue sclera includes multiple connective tissue disorders, such as

  1. brittle cornea syndrome
  2. Marshall and Stickler syndrome
  3. POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes) syndrome
  4. Marfan syndrome,
  5. Ehlers–Danlos syndrome,
  6. pseudoxanthoma elasticum, and
  7. Willems De Vries syndrome
  8. Bone and blood disorders also on the list include
  • Diamond–Blackfan anemia,
  • severe iron deficiency anemia,
  • Juvenile Paget’s disease, and
  • acid phosphatase deficiency

Severe forms of osteogenesis imperfecta are most often diagnosed early in life, but mild cases may not be noted until later in life. The blue-gray color of the sclera is due to the underlying choroidal veins which show through. This is due to the sclera being thinner than normal because the defective type I collagen is not forming correctly 6. The sclera is a dense poorly vascularized connective tissue structure composed of types I, III, IV, V, VI, and VIII collagen, as well as elastin, proteoglycans, and glycoproteins.


Homoeopathy today is a rapidly growing system and is being practiced all over the world. It strength lies in its evident effectiveness as it takes a holistic approach towards the sick individual through promotion of inner balance at mental, emotional, spiritual and physical levels. When  is concerned there are many effective medicines available in Homoeopathy , but the selection depends upon the individuality of the patient , considering mental and physical symptoms

Few homoeopathic medicine can be thought of in the treatment of blue sclera are:

carboneum oxy., plumbum, belladonna, stramonium etc.