Granulomatosis with polyangiitis is an uncommon disorder that causes inflammation of the blood vessels in your nose, sinuses, throat, lungs and kidneys.

Formerly called Wegener's granulomatosis, this condition is one of a group of blood vessel disorders called vasculitis. It slows blood flow to some of your organs. The affected tissues can develop areas of inflammation called granulomas, which can affect how these organs work.


Signs and symptoms of granulomatosis with polyangiitis can develop suddenly or over several months. The first warning signs usually involve your sinuses, throat or lungs. The condition often worsens rapidly, affecting blood vessels and the organs they supply, such as the kidneys.

Signs and symptoms of granulomatosis with polyangiitis might include:

  • Pus-like drainage with crusts from your nose, stuffiness, sinus infections and nosebleeds
  • Coughing, sometimes with bloody phlegm
  • Shortness of breath or wheezing
  • Fever
  • Fatigue
  • Joint pain
  • Numbness in your limbs, fingers or toes
  • Weight loss
  • Blood in your urine
  • Skin sores, bruising or rashes
  • Eye redness, burning or pain, and vision problems
  • Ear inflammation and hearing problems


The cause of granulomatosis with polyangiitis isn't known. It's not contagious, and there's no evidence that it's inherited.

The condition can lead to inflamed, narrowed blood vessels and harmful inflammatory tissue masses (granulomas). Granulomas can destroy normal tissue, and narrowed blood vessels reduce the amount of blood and oxygen that reaches your body's tissues and organs.


Granulomatosis with polyangiitis can occur at any age. It most often affects people between the ages of 40 and 65.


Besides affecting your nose, sinuses, throat, lungs and kidneys, granulomatosis with polyangiitis can affect your skin, eyes, ears, heart and other organs. Complications might include:

  • Hearing loss
  • Skin scarring
  • Kidney damage
  • A loss of height in the bridge of the nose (saddling) caused by weakened cartilage
  • A blood clot forming in one or more deep veins, usually in your leg


Few homoeopathic medicine which effectively manages the case:

bryonia, kali carb, lycopodium, hepar sulph, etc.