Aniridia is a congenital, hereditary, bilateral, extreme form of iris hypoplasia that may be associated with other ocular defects. It is bilateral in nature that affects all ocular tissue but most notably results in iris hypoplasia
This can occur in isolation without systemic involvement, due to P AX6 gene mutation, or as part of the Wilms tumor aniridia-genitourinary anomalies-retardation (WAGR) syndrome, which ii caused by deletion ofllpl3, including PAX6 and adjacent WTI locus.
Aniridia is marked by partial or complete absence of the iris of the eye. Vision is preserved in some patients with mild cases of aniridia. This condition occurs when the iris fails to develop normally before birth in one or both eyes. Typically, aniridia can be seen from birth. Aniridia can occur as a single abnormality or can be one of many symptoms in an underlying condition.
CLINICAL FEATURES OF ANIRIDIA
- Iris hypoplasia
- optic nerve hypoplasia
- foveal hypoplasia leads to nystagmus is usually apparent by 6 weeks of age due to poor vision.
DIAGNOSIS OF ANIRIDIA
Slit lamp examination - is important to detect iris and papillary abnormalities; corneal opacification and vascularization, cataract, and glaucoma may also be detected.
Slit lamp fundoscopy - foveal hypoplasia and any associated optic disc malformations.
Optical coherence tomography (OCT) - in the presence of nystagmus and in young children.
High-frequency ultrasound biomicroscopy (UBM
MANAGEMENT: Patients should have regular eye examinations. Correction of refractive errors and treatment of amblyopia are simple and essential measures. Optical low vision aids for those with significant visual impairment and help with schooling and social support should be provided. Tinted or photocromic lenses can be used to reduce light sensitivity associated with the large papillary aperture.
HOMOEOPATHIC MANAGEMENT FOR ANIRIDIA :
Homeopathy medicines for Aniridia are a natural remedy with no side effects but you need to have a proper consultation. The approach involves strengthening the body’s own healing system to repair organs and make them disease-free. These holistic approach helps your body to fight the disease condition be it an auto-immune disorder, an inflammatory disease or an infection. It starts by moderating the immune system, eradicating the disease at the root and preventing a recurrence.
Euphrasia Officinalis – it is an excellent medicine for eye disorders with this king of symptoms, swelling of the lids. Frequent inclination to blink. Free discharge of acrid matter. Sticky mucus on cornea; must wink to remove it. Pressure in eyes. Little blisters on cornea. Opacities.
Pulsatilla Nigricans - Itching and burning in eyes. Profuse lachrymation and secretion of mucus. Lids inflamed, agglutinated, Styes. Veins of fundus oculi greatly enlarged
Physostigma - Twitching of ocular muscles. Lagophthalmus. Muscæ volitantes; flashes of light; partial blindness Profuse lachrymation. Spasm of ciliary muscles, with irritability after using eyes. Increasing myopia.
Natmur - Eyelids heavy. Muscles weak and stiff. Letters run together. Sees sparks. Fiery, zigzag appearance around all objects. Burning in eyes. Give out on reading or writing. Stricture of lachrymal duct with suppuration. Escape of muco-pus when pressing upon sac
Silicea- Aversion to light, especially daylight; it produces dazzling, sharp pain through eyes; eyes tender to touch; worse when closed. Vision confused; letters run together on reading